Add the flour, sugar, soda and salt to the bowl of an electric mixer and mix on low speed until just combined. Add the butter, 1 tablespoon at a time, beating each until it makes coarse crumbs in the dry ingredients. With the mixer on low speed, add in the vanilla extract, eggs and buttermilk. Beat the batter on medium speed for 1 to 2 minutes until smooth and fluffy. It will be thick!
Place the cherries, blueberries and strawberries in a large bowl. Toss with the 2 tablespoons flour. Use a spatula to fold the berries and cherries into the cake batter.
Spread the batter evenly in the greased pan. Sprinkle the crumb mixture evenly over top. Bake the cake for 40 to 45 minutes, or until the center is set and no longer jiggly. Let the cake cool in the pan for 30 minutes, then remove it and let cool completely before cutting.